MPDiol® Glycol
None of the subjects tested with neat material or a 50% aqueous solution exhibited any reactions.
1,3 Butylene Glycol
None of the subjects tested with neat material or a 50% aqueous solution exhibited any reactions.
Propylene Glycol USP
Five subjects exhibited a minimal response (+1) to neat Propylene Glycol USP (PG USP) after the first patch and one of these subjects also had a minimal response after the second patch. None of these five subjects exhibited further response throughout the remainder of the study. Another subject exhibited a minimal reaction after the first patch and a marked reaction (+3) on day 2. This individual was excluded from further testing with neat Propylene Gycol. None of the subjects, including the subject that had a marked reaction to neat PG USP, reacted to the 50% aqueous PG USP solution. There was no indication that PG USP caused cumulative dermal irritation.
Dipropylene Glycol - Fragrance Grade
One subject exhibited minimal reactions (+1) after the first 4 patches with neat test material. However, this subject did not exhibit further reactions throughout the remainder of the study. A minimal response (+1) was noted in one subject only after the first patch with the 50% aqueous Dipropylene Glycol solution. There was no indication that Dipropylene Glycol caused dermal cumulative irritation.
Tripropylene Glycol
None of the subjects tested with neat material or a 50% aqueous solution exhibited any reactions.
Control - Water
There were no reactions to the vehicle control.